![]() One hides out in a decorative shell, the other buzzes ‘round like a carousel. Today’s debate is a poisonous, blood-sucking battle between two dangerous creatures. Ad hominem attacks and bandwagon fallacies, be gone! So if you’re looking to ignite a funny, feisty debate on your next roadtrip, or just want some amusing arguments for your kids to consider while they fall asleep… tune into Smash Boom Best, where we make debate – a blast! To top it off, our State of Debate segment shows listeners how to identify logical fallacies in the wild. Our star-studded line-up of debaters use facts and passion to make their case, teaching listeners how to defend their opinions along the way! Past debaters include Tim Platt, cast member of the comedy narrative play podcast Rude Tales of Magic, comedian and writer Jenny Yang, Minneapolis-based rapper NUR-D, comedian and creator of the Story Pirates Peter McNerney, Radio Ambulante’s Daniel Alarcón, journalist and host of Into It Sam Sanders, host of Terrible, Thanks for Asking Nora McInerney, food-writer Kenji Lopez-Alt and many, many more. Every episode takes two cool things, smashes them together and lets you decide which is best: Pikachu vs. Smash Boom Best is a funny, smart debate show for kids and families from the makers of the award-winning podcast, Brains On! from APM Studios.
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![]() 14.7% of shares of all “Pharmaceutical preparations” companies are owned by company insiders. Comparatively, 39.9% of shares of all “Pharmaceutical preparations” companies are owned by institutional investors. Insider and Institutional OwnershipĦ1.7% of Mineralys Therapeutics shares are owned by institutional investors. Given Mineralys Therapeutics’ stronger consensus rating and higher possible upside, research analysts clearly believe Mineralys Therapeutics is more favorable than its rivals. As a group, “Pharmaceutical preparations” companies have a potential upside of 70.60%. The acquisition of Horizon will drive growth in Amgen's revenue and non-GAAP EPS and is expected to be accretive from 2024.Mineralys Therapeutics presently has a consensus price target of $36.00, indicating a potential upside of 347.76%. Additionally, the potential new medicines in Horizon's pipeline strongly complement our own R&D portfolio. “Amgen's decades of leadership in inflammation and nephrology, combined with our global presence and world-class biologics capabilities, will enable us to reach many more patients with first-in-class medicines like TEPEZZA, KRYSTEXXA and UPLIZNA. "The acquisition of Horizon is a compelling opportunity for Amgen and one that is consistent with our strategy of delivering long-term growth by providing innovative medicines that address the needs of patients who suffer from serious diseases,” Amgen Chairman and CEO Robert A. The deal will generate cash flow of $10 billion combined over twelve months through Q3 2022, the announcement said. In addition, the two companies together will utilize Amgen’s research and development, process development and global manufacturing expertise in biologic medicines to benefit Horizon's approved medicines and potential new medicines. ![]() Amgen is aligned with that commitment and passion and will continue to the value of the current portfolio and pipeline and accelerate the ability to reach more patients globally."Īccording to Amgen, the deal will strengthen its portfolio of innovative therapeutics with complementary medicines from Horizon that address the needs of patients with rare diseases. These accomplishments are all rooted in our employees' deep commitment, dedication and personal passion for those impacted by rare, autoimmune and severe inflammatory diseases. “We have accomplished a tremendous amount for patients, their families and our customers, and created significant value for shareholders. "In nearly 15 years, we have built one of the fastest growing and most respected companies in the biotechnology industry from the ground up,” President and CEO of Horizon Therapeutics Tim Walbert said in a statement. It is one of the biggest healthcare deals announced in 2022. The deal brings together Amgen––which is focused on six therapeutic areas: cardiovascular disease, oncology, bone health, neuroscience, nephrology and inflammation––and Horizon, which develops medicines for rare, autoimmune and severe inflammatory diseases. ![]() 29, 2022, and a premium of 19.7% above the closing price of $97.29 on Dec. That’s a premium of 47.9% above the closing price of $78.76 per share on Nov. American biopharmaceutical company Amgen is acquiring Horizon Therapeutics, a biopharmaceutical company based in Dublin, for $27.8 billion.Īmgen’s newly created subsidiary, Pillartree Limited, will acquire Horizon Therapeutics for $116.50 per share in cash. ![]() Lobar pneumonias have specific appearances, which can be explained by the anatomical relationships of the lobes of the lung to their surrounding structures. Where the horizontal fissure is concerned, this can sometimes be seen as a sharp border in the mid-zone of the right hemithorax when there is consolidation in the alveoli either above it (in the right upper lobe) or below it (in the right middle lobe).īronchopneumonia appears on a chest X-ray as bilateral patchy shadows and typically predominates at the lung bases: This is termed the silhouette sign and is often described as causing a ‘loss of clarity’. In the lobes which abut the heart anatomically, it therefore, becomes impossible to distinguish where the lung ends, and the heart begins. Affected alveoli become as dense as soft tissue structures such as the heart. In the case of pneumonia, air within the alveoli is replaced by inflammatory exudate and pus. X-rays travelling through lung tissue cast less of a shadow than those passing through the soft tissues of the mediastinum or abdomen. If we apply this to a chest X-ray, it becomes evident that the only structures we can appreciate are those where there is a density change at their border with neighbouring structures. Shadow of two hands forming the shape of a bird, image sourced from Wikipedia The combination of their individual silhouettes adds up to become a bird, a rabbit, a dog and all manner of other possibilities. The game works because you cannot tell where one hand begins and the other ends. This sign can be difficult to conceptualise, but the simple children’s game of hand shadow puppets is a helpful way of assisting our understanding of it. Loss of these normal silhouettes on an AP chest X-ray is generally indicative of the site of the pathology. Much is made of this sign in radiology and, once it is properly understood, it is extremely useful in localising areas of airspace opacity, atelectasis, or a mass within the lung. It is something of a misnomer as it actually represents the loss of a normal silhouette. The silhouette sign refers to the loss of normal borders between thoracic structures on a chest X-ray. How can shadow puppets help us to understand chest X-rays? Chest X-rays are the initial modality of investigation in the majority of cases, and a sound understanding of the chest X-ray features of pneumonia is vital for all front-line clinicians that encounter and treat it. Streptococcus pneumoniae is by far the most common causative organism. Pneumonia is characterised by exudation and consolidation into the alveoli, and in the U.K. will develop community-acquired pneumonia. Every year between 0.5% and 1% of adults in the U.K. ![]() Pneumonia, which is defined as inflammation of the lung, is a common cause of morbidity and mortality around the world. Flashlights should feature this number prominently it’s a red flag if they don't.Īnother red flag is when a flashlight claims to have an outrageous number of lumens such as 9 million, as seen throughout ads on the internet. Here are some features you should learn about before buying. There’s a wide variety of flashlights, and their uses can be very situation- or job-specific. A flashlight’s shape is far more versatile. Phones can be uncomfortable and inconvenient when doing certain tasks or trying to use both hands.In emergency situations, your phone’s battery is too valuable to waste using the flashlight.The tight area on the phone also limits heat dissipation, so a phone flashlight can’t be used for too long at max brightness or your phone might overheat. A bigger reflector makes the beam more concentrated and reaches farther distances. The biggest cell phones on the market are about 8mm thick overall, and the light has no reflector the reflector alone on dedicated keychain flashlights is over 15mm in depth.The light on your phone reaches a maximum brightness of approximately 50 lumens, which pales in comparison to the 120 lumens on a basic flashlight, like the AAA-powered $9 Lumintop EDC01, for example.Here’s why it’s smart to have a high-quality flashlight on hand, rather than just getting by with your phone’s light: ![]() However, they're no match for even the smallest dedicated flashlight. The flashlight feature on smartphones (which basically turns the phone’s camera flash into a flashlight) has been a game changer for random encounters with darkness. Most cellphones nowadays have flashlights, which can give you a little light in a pinch, but there are reasons why you may also want to own a dedicated tool (or a few of them) that has a far superior light source and can last a lifetime. You simply won't find the best quality and variety of flashlights in supermarket aisles. And if you have a job or hobby that demands regular flashlight use, you’ll not only want a product you can rely on but also includes certain features that fit your tasks. You want to know that your flashlight will be ready to go whenever a storm approaches and knocks out your power, whether next week or in five years. Many people buy flashlights to prepare for emergencies. ![]() Why would anyone pay more than a few bucks for a basic flashlight? Durability, reliability and versatility, for starters. From $1 plastic flashlights to luxury pieces handcrafted from zirconium that cost well into the thousands, there are a lot to choose from. They’re so common that many people are unaware of how deep and varied the flashlight market is. Nowadays, flashlights are incorporated into cell phones and keychains and can be purchased at supermarkets, hardware stores, gas stations and more. Since its invention in 1898, the flashlight has been an invaluable tool for human beings, who, unlike cats, are unable to see in the dark. Low power for current standards, no buttons. ![]() Rather than giving us carbon copies as army-builders, LEGO opted to give us two unique LEGO Endor Rebel Trooper minifigures! Nice touch, LEGO! It’s a shame that this set is too expensive for most folks to army-build Endor Troopers with. ![]() The Jedi Luke minifigure comes with the Death Star Final Duel set and we’re getting R2-D2 and C-3PO figures with the 2015 LEGO Star Wars Advent Calendar, so I believe that covers all of the characters who should be present in the Imperial Shuttle Tydirium getting a release this summer/fall. The LEGO Endor Princess Leia minifigure includes a nice-looking soft goods camouflage poncho, but Endor Han’s trench coat is unfortunately just printed onto the figure. The 75094 Imperial Shuttle Tydirium set includes five minifigures: a Chewbacca figure and new versions of LEGO Endor Leia, Endor Han Solo and two Endor Rebel Trooper minifigures. And for the very first time, the Tydirium ship will be able to really go on the offensive, as it’s packing the powerful spring-loaded missiles introduced last year for the very first time! (I love these spring-loaded missiles!). ![]() The Imperial Shuttle Tydirium isn’t the most colorful set around (nor should it be), but the build for this set is really quite beautiful. Of the five new summer LEGO Star Wars sets coming this year, two are from the Original Trilogy (Return of the Jedi, to be specific): the very cool LEGO Death Star Final Duel set I discussed last week, and a brand-new LEGO Imperial Shuttle Tydirium!Īs fans of the Star Wars Original Trilogy will remember, the Tyridium is the specific Imperial Shuttle ship that the Rebels use to travel discretely to Endor (rather than the Imperial Shuttle that Emperor Palpatine arrives at the Death Star II on). Because the enforced street date for Star Wars Episode VII toys isn’t until fall, we’re going to get a smaller-than-usual LEGO Star Wars Summer 2015 sets wave this year (with a ton of LEGO Star Wars The Force Awakens sets coming in the fall). ![]() Mario needs help writing his own fairy tale. When Baby Bop is reluctant to donate her toys, Barney and his friends help teach her the importance of sharing.īarney and the children help Miss Jo find her cat, "Cody". While learning about on and off, Barney and his friends help Baby Bop costumes for her teddy bear. While waiting for a special fountain delivery, Barney and the children discover the delights of the park. Craig Boarini (played Mel the Mailman in " Who's Your Neighbor?").Georgia Foy (played Officer Phillips in " Who's Your Neighbor?"). ![]()
![]() Harvey to the Rescue (cameo), A Bad Day for Harold the Helicopter (cameo), Elizabeth the Vintage Lorry (cameo), It's Only Snow (cameo), Twin Trouble, The World's Strongest Engine (cameo), Scaredy Engines, Percy and the Haunted Mine (cameo), Middle Engine (cameo), James and the Red Balloon (does not speak), Jack Frost (cameo), Percy's Chocolate Crunch (cameo), Toby Had a Little Lamb and Edward the Very Useful Engine (does not speak) Season 3 Gordon and the Famous Visitor, Donald's Duck, Thomas, Percy and the Dragon (cameo), Diesel Does it Again, Thomas, Percy and the Post Train, Trust Thomas (does not speak), Buzz, Buzz, All at Sea, Tender Engines, Escape, Oliver Owns Up, Bulgy, Percy, James and the Fruitful Day and Thomas and Percy's Christmas Adventure (cameo)Ĭranky Bugs, Horrid Lorry (cameo), A Better View for Gordon (cameo), Bye George!, Baa! (cameo), Put Upon Percy (does not speak), Double Teething Troubles, Thomas and the Rumours (cameo), Sir Topham Hatt's Holiday (cameo) and Make Someone Happy (cameo)
![]() When using Krita for animation, you should switch to the Animation workspace, which has all the necessary dockers on display. Krita has an easy-to-use interface for those familiar with animation software to a certain degree. Here is how Krita and Adobe Animate compare in terms of ease of use, basic and complex animation capabilities, and cost. However, the case of comparing programs usually comes down to which is the best software for you and your needs. When it comes to creative software, it’s hard to determine which product is best between two well-established programs. Another option is to look through Krita threads on Reddit for tips, advice, and inspiration. You can also follow YouTube tutorials on the specific actions you want to take in the program. To understand how to use Krita more in-depth and create impressive designs, try out a Krita course from Udemy or Skillshare. I recommend you read the latest Krita manual to learn the basics of the program. Krita focuses on letting you get straight to drawing and animating rather than confusing you with too many buttons and features.ĭespite the relatively easy interface, like any graphic design and digital drawing software, the program can be overwhelming to complete beginners. If you understand the basics of animation, you can find your way around the program reasonably easily. However, some aspects of Krita are vastly different from Adobe, such as using Dockers instead of panels. You can catch on faster if you have experience using Adobe products because it shares similar tools and functions. Krita is a relatively beginner-friendly program, and most of its interface is straightforward. How easy is it to make animations with Krita? You can add extensive edits to this panel. The animation curves docker is used to add minor frames between the main content, known as tweening. You can use the onion skin docker to change the skin's look, allowing you to see previous frames more clearly. The onion skin docker helps control how you see the different frames placed on top of each other so you can see a complete view of all the frames and how they work together. You can organize the different parts of your animation using this docker by moving the artboards around, adding new artboards, or deleting artboards. The storyboard docker helps keep track of your storyboards. You can also add audio to your work using this docker. You can also playback your animation in this docker to test how the animation looks and the time limits of each movement. When you add new layers to this docker, they will also appear in your standard Layer docker. ![]() The animation timeline docker lets you view and control the various frames you add to your animation and lets you manage your layers. The features that Krita does currently offer for animation include the following important dockers: The Animation Timeline Docker Krita offers frame-by-frame raster animation, which is perfect for beginners and those exploring animation but won’t offer a complete solution for extensive professional animation. Krita is a drawing and illustration graphic design program that offers several tools and functions to create digital drawings and artworks. The only reason why I don’t recommend Krita as an overall solution is that the program isn’t currently focused on animation. Passionate creatives have developed Krita, and the open-source nature means that creatives are continuously working to improve the platform. The program is 100% open-source and free to download and use. ![]() If you want to explore animation and find out whether it’s something you want to take seriously, Krita is an excellent place to start. How easy is it to make animations with Krita?. ![]() ![]() The game Company of Heroes 2 download torrent on your computers you can on our website by clicking on the download button just below. Thus, you can give commands, make important decisions and independently influence the course of history. The game provides the ability to manage an entire army thanks to a well-designed control system. In order to adapt to the surrounding world, the game has several dozen different missions and battles.Įach player can not only carry out various orders and commands, but also give them. ![]() Indeed, in order to become a great commander, you need to work on yourself for a long time. 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Players command the Soviet Red Army, and all battles take place on the fields of the Eastern Front. Each of them gives players small clues, which in the end will fold into one big puzzle and give a complete picture of what really happened. All events in the game are closely interconnected. It is not known exactly why he is imprisoned, but his former boss will have to find out. The main character is Lieutenant Isakovich, who is serving time in Siberia. The story begins from the moment when the war has already ended. Unlike the first game, which was dedicated exclusively to the Normandy operation, the second part covers several events from different years during the Second World War. All you need to do is go to the corresponding site. Company of Heroes 2 torrent download you can right now. It was released in 2013 by Relic Entertainment. This is a continuation of the legendary computer game in the genre of real-time strategy. One of the most popular games of this kind is Company of Heroes 2. They give you the opportunity to experience all the dangers on the battlefield, feel like a real soldier and hero. War games are very popular in the modern world. ![]() Some indication has been given of voyages made by the vessels. ![]() No lists were available for certain notable ships, or for years ending in 5, eg. The entry "NA" indicates that the relevant box was not available, so there is a good chance that the documents exist and are held elsewhere, probably among those retained by the Public Record Office and the National Maritime Museum. In some cases there may be only a single sheet recording the release of a crew member on the other hand, in later years, several documents sometimes make up one crew list. The number of items entered for each year is the number of documents, not of complete returns. It is planned to make at a later date an index of Owners and Masters. It must be emphasised, therefore, that these details should be used with caution. Users should note that the particulars of Owners, Masters and Voyages have been extracted by a number of different people, most of them inexperienced in this work, and it has not been possible to check more than obvious discrepancies. The additional information given here was gathered partly from the original registration of the vessels, but mainly from the documents themselves. The primary purpose of this list is to provide the names of ships for which crew lists and agreements are deposited in the Southampton Record Office, with the dates and number of items. In the second and third categories, the ships had first to be identified, and these sections are by no means comprehensive in any case, we could only have the documents if they were not required by the port of registry. In the first category, the attempt was made to obtain all available records except for those of vessels known to be yachts under 40 tons or dumb barges. Secondly, we claimed vessels which had been built in Southampton and, thirdly, ships which mainly used this port, especially the passenger liners which were so important to Southampton but few of which were registered here. The first, and by far the largest, consists of ships registered in Southampton. When the documents were made available by the Public Record Office in 1966, this office asked for the records of ships in three categories. The Official Log is not the full ship's log, but only a record of certain incidents relating to the crew and sometimes to passengers, such as deaths on board, which had to be reported to the Registrar. These agreements and crew lists usually include such information as the destination of the ship and the names of individual crew members with age, rank, place of birth, former ship and wage. Vessels engaged in coastal or cross-Channel trade made a return half-yearly, while ships going to more distant ports completed an agreement for each voyage. These records consist of the Crew Lists and Ships' Agreements, with some Official (Crew) Log Books, which were required by law to be sent to the Registrar of Shipping and Seamen for ships registered in the United Kingdom. |
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